Our resources
Protein expression
A central technical infrastructure of the laboratory is a high-throughput mammalian protein expression system. We use this to express the entire ectodomains of human cell surface receptors as soluble recombinant proteins. We have designed and built bespoke protein purification apparatus that enables us to conveniently express and purify hundreds of different proteins.
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Human receptors
The laboratory has compiled a large resource of protein expression plasmids that encode the entire extracellular domains of human cell surface proteins. This plasmid receptor resource underpins many of the discoveries that we have made. These plasmids are openly available at Addgene.
2510 fulfilled requests for our plasmids. |
Infection models
For our pre-clinical vaccine testing for parasitic diseases, we have established bioluminescent murine infection infection models which include Trypanosoma vivax and Trypanosoma congolense.
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York technology facility
Adjacent to the laboratory is the York technology facility - a set of five research infrastructures that provide managed and expert-guided access to the latest techniques for the biosciences:
• Protein Production Laboratory (Bacterial and eukayotic recombinant protein) • Imaging and Cytometry (Confocal and electron microscopy) • Metabolomics & Proteomics (Mass spectrometry) • Molecular Interactions (Biophysical interaction quantitation) • Genomics and Bioinformatics (Genome sequencing and analysis) |
York Structural Biology Laboratory
We are located adjacent to the York Structural Biology Laboratory who have access to X-ray crystallography, Cryo-EM, and NMR instrumentation housed in the new Eleanor and Guy Dodson Building.
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